What are the diagnostic requirements for acute myeloid leukemia?

Published on May 31, 2017 in Diagnosis

Keith W. Pratz, MD
Assistant Professor of Oncology
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins University
Baltimore, Maryland

Welcome to Managing AML. I am Dr. Keith Pratz. I am frequently asked, “What are the diagnostic requirements for acute myeloid leukemia?” The diagnostic requirements for acute myeloid leukemia are a finding of greater than 20% myeloblasts in the blood or the bone marrow; in certain subtypes of acute myeloid leukemia, such as translocation 8;21 and inversion 16, the current WHO (World Health Organization) criteria allow for the diagnosis of acute myeloid leukemia to be made in patients who have fewer than 20% blasts; and a recent revision to the WHO criteria has slightly changed the diagnosis for pure erythroid leukemia to require those patients to have greater than 20% blasts irrespective of the erythroid component of the bone marrow. In general, greater than 20% blasts is required for acute myeloid leukemia diagnosis, except in certain genetic subtypes such as translocation 8;21 and inversion 16. Thank you for reviewing this activity.

Last modified: May 18, 2017

Related Items by Author

Keith W. Pratz, MD
Diagnosis Published on May 31, 2017
Keith W. Pratz, MD
Diagnosis Published on May 31, 2017