Novel Therapeutic Approaches in Newly Diagnosed Younger Patients with AML

Novel Therapeutic Approaches in Newly Diagnosed Younger Patients with AML

CME, CPE
Pinkal Desai, MD, MPH
Release Date: November 30, 2018

Expiration Date: November 30, 2019

Treatment options for younger patients with newly diagnosed AML are expanding, with the recent approvals of several targeted therapies, as well as clinical trials investigating novel agents. In this interview, Dr. Pinkal Desai discusses the diagnosis and prognosis of younger people with AML, current standards of care, and key data from clinical trials assessing novel targeted combination therapies to optimize the management of this unique patient population.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., Helsinn Healthcare SA, and Jazz Pharmaceuticals

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Managing High-Risk and Relapsed/Refractory AML: Where Is Research Headed Next?

Managing High-Risk and Relapsed/Refractory AML: Where Is Research Headed Next?

CME, CPE
Amir T. Fathi, MD
Release Date: November 28, 2018

Expiration Date: November 28, 2019

With the treatment landscape for acute myeloid leukemia (AML) continuing to expand, it is critical for physicians to be up-to-date on the emerging role of FDA-approved therapies and combinations as well as those being explored in clinical trials. In this activity, Dr. Amir Fathi describes the emerging role of FLT3 and IDH1/2 inhibitors in AML. He also discusses the treatment paradigm for non-intensive, upfront therapy when caring for older or less functionally robust patients with the disease.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., Helsinn Healthcare SA, and Jazz Pharmaceuticals

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Optimizing Treatment in the Older Patient with AML

Optimizing Treatment in the Older Patient with AML

CME, CPE
Farhad Ravandi, MD
Release Date: November 06, 2018

Expiration Date: November 06, 2019

AML is typically a disease of older adults, a group of patients that fares significantly worse than their younger counterparts. As the treatment landscape for AML continues to expand, clinicians must have a practical, working knowledge of important considerations when managing older patients to individualize therapy. In this activity, Dr. Farhad Ravandi discusses strategies to optimize treatment in older AML patients, describing how age is a factor in AML and outlining emerging approaches to managing this difficult-to-treat patient population.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., Helsinn Healthcare SA, and Jazz Pharmaceuticals

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The Evolving Standard of Care in AML: FLT3 Inhibitors

The Evolving Standard of Care in AML: FLT3 Inhibitors

CME, CPE
Alexander Perl, MD
Release Date: October 16, 2018

Expiration Date: October 16, 2019

New therapies are helping to improve survival in patients with AML who present with FLT3 mutations. In this activity, Dr. Perl reviews the current status and future direction of first- and second-generation FLT3 inhibitors, both approved and in clinical trials.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., Helsinn Healthcare SA, and Jazz Pharmaceuticals

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Evolving Paradigms in AML: Symposium Replay

Evolving Paradigms in AML: Symposium Replay

CME, CPE, CNE
Farhad Ravandi, MD – Chair; Naval Daver, MD; Guillermo Garcia-Manero, MD; and Richard Stone, MD
Release Date: October 12, 2018

Expiration Date: October 12, 2019

Evolving Paradigms in AML: Navigating New Therapeutic Opportunities in the Frontline and Relapsed Settings is a digitally captured archive of a live independent satellite symposium held on September 13 during the SOHO 2018 Meeting. The medical landscape of AML continues to evolve, as evidenced by the approval of five new agents since April 2017 and the anticipated approval of additional novel agents in the very near future. An explosion of clinical trials and updated practice guidelines – coupled with a multitude of therapies in late-stage development – has created the vast challenge of staying up-to-date with clinical evidence impacting practice and patient outcomes. Our experts provide a high-level overview of the latest data from newly diagnosed to relapsed disease, focusing on the most current therapeutic landscape.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Daiichi Sankyo, Inc., Helsinn Healthcare SA, and Jazz Pharmaceuticals.

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The Expanding Landscape: Promising Novel Agents in Clinical Trials

The Expanding Landscape: Promising Novel Agents in Clinical Trials

CME, CPE
Daniel A. Pollyea, MD
Release Date: September 28, 2018

Expiration Date: September 28, 2019

As the treatment landscape for both newly diagnosed and relapsed/refractory AML continues to expand, clinicians must have a practical, working knowledge of the efficacy and safety data of recently approved therapies beyond FLT3 inhibitors as well as novel agents in clinical development. In this activity, Dr. Daniel Pollyea describes several of the current and emerging therapies that are being investigated in clinical trials as treatment for AML.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., Helsinn Healthcare SA, and Jazz Pharmaceuticals

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EHA 2018 Annual Congress Highlights in Acute Myeloid Leukemia

EHA 2018 Annual Congress Highlights in Acute Myeloid Leukemia

CME, CPE, CNE
Jorge E. Cortes, MD; Mark J. Levis, MD, PhD; Keith W. Pratz, MD; and Eytan M. Stein, MD
Release Date: August 22, 2018

Expiration Date: August 22, 2019

In this activity, view video highlights from the 2018 European Hematology Association (EHA) Annual Congress and listen as experts share their insights on a variety of abstracts covering topics including, but not limited to: the efficacy and safety of emerging drugs for newly diagnosed and relapsed/refractory AML; monotherapy and combination treatments in clinical trials; and sequencing of therapy for relapsed/refractory disease.

  • Chapter 1: Key Findings in AML: An Overview
  • Chapter 2: Quizartinib: An Emerging Treatment Option for Relapsed/Refractory FLT3 ITD AML
  • Chapter 3: Strategies for Achieving Durable Responses in Elderly AML Patients
  • Chapter 4: Enasidenib in Newly Diagnosed and Relapsed/Refractory Mutant IDH2-positive AML
  • Chapter 5: Emerging Combinations and Therapies in Newly Diagnosed and Relapsed/Refractory AML

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., and Helsinn Healthcare SA

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ASCO 2018 Annual Meeting Highlights in Acute Myeloid Leukemia

ASCO 2018 Annual Meeting Highlights in Acute Myeloid Leukemia

CME, CPE, CNE
Naval Daver, MD; Guillermo Garcia-Manero, MD; Mark J. Levis, MD, PhD; Richard Stone, MD; and Eunice S. Wang, MD
Release Date: July 31, 2018

Expiration Date: July 31, 2019

In this activity, participants will hear key highlights of several significant scientific updates in acute myeloid leukemia (AML) presented at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting. Experts will share insights on a variety of abstracts covering topics including: treatment selection strategies, targeted combination therapies, immunotherapies, and novel agents for both newly diagnosed and relapsed/refractory AML patients. Don’t miss this opportunity to see how the future of treatment in AML is evolving, and how these changes may positively impact patient outcomes.

  • Chapter 1: Key Findings in AML: An Overview
  • Chapter 2: New Data from the Ongoing Phase 1 Study Evaluating Single-Agent IDH1 Inhibitor AG-120 in Relapsed/Refractory AML
  • Chapter 3: Two Phase 3 Trials in Progress: HDAC Inhibitor Pracinostat in Combination with Azacitidine; NEDD Inhibitor Pevonedistat + Aza
  • Chapter 4: Post hoc Analysis of Clinical Activity of Quizartinib in Patients with Prior TKIs
  • Chapter 5: IDH1 and IDH2 Inhibitors in Combination with Aza in the Upfront Setting
  • Chapter 6: The Role of Nivolumab in Maintenance Therapy; BCL-2 Inhibitor Studies in Newly Diagnosed AML; Impact of NGS on Therapy Selection

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., and Helsinn Healthcare SA

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Are IDH2 Inhibitors Right for Your AML Patient?

Are IDH2 Inhibitors Right for Your AML Patient?

CME, CPE
Hetty E. Carraway, MD
Release Date: May 15, 2018

Expiration Date: May 15, 2019

The treatment landscape for acute myeloid leukemia (AML) continues to evolve with several recent FDA approvals of novel treatment options, including an isocitrate dehydrogenase 2 (IDH2) inhibitor. Mutated IDH2 is present in 8-19% of patients diagnosed with AML, making it an important target to treat when managing the disease. View this activity and hear how Dr. Carraway discusses the role of IDH2 inhibitors in the diagnosis, prognosis, and treatment of patients with IDH2-mutated AML. She will outline a treatment plan for managing these patients in the relapsed or refractory setting, taking into consideration patient selection, proper administration, and potential adverse events. Furthermore, Dr. Carraway will identify the latest updates in emerging data related to the safety and efficacy of IDH2 inhibitors currently in clinical trials.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Daiichi Sankyo, Inc., and Helsinn Healthcare SA.

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ASH 2017 Annual Meeting Highlights in Acute Myeloid Leukemia

ASH 2017 Annual Meeting Highlights in Acute Myeloid Leukemia

CME, CPE, CNE
Naval Daver, MD; Guillermo Garcia-Manero, MD; Jeffrey E. Lancet, MD; Keith W. Pratz, MD; Eytan M. Stein, MD
Release Date: December 21, 2017

Expiration Date: December 21, 2018

In this activity, participants will learn about key highlights of the latest and most impactful data in acute myeloid leukemia (AML), presented at the 2017 American Society of Hematology (ASH) Annual Meeting.

Chapter 1: Developments in FLT3 Inhibitors, Chemotherapy, and Small Molecule Inhibitors

Chapter 2: Pracinostat with Azacitidine in Elderly Patients

Chapter 3: CPX-351 vs 7+3 in Older Adults: Efficacy and Safety Reported in Clinical Trial

Chapter 4: Biomarker-driven Treatments: Ivosidenib, Enasidenib, and Sy-1425

Chapter 5: Combination Therapies Involving Gilteritinib and Venetoclax

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, Jazz Pharmaceuticals, Inc., and Novartis Pharmaceuticals.

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The Evolving Treatment Landscape in AML

The Evolving Treatment Landscape in AML

CME, CPE
Elias Jabbour, MD
Release Date: November 28, 2017

Expiration Date: November 28, 2018

Due to the recent advances in the knowledge of molecular profiles, karyotyping, and the physiopathology of the disease, we are able to classify AML into different categories: favorable, intermediate, and adverse; all which have implications into the treatment and the outcome of the disease. View this activity and hear how Dr. Jabbour outlines the evolving treatment landscape and the identified subsets of AML that will help set the stage for treatment selection and sequencing. He will share with you an overview of the newly approved and emerging treatment options in clinical trials and offer insights into defining a new treatment plan in the era of expanded opportunities.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, Jazz Pharmaceuticals, Inc., and Novartis Pharmaceuticals.

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Novel Treatment Combinations in Development for AML: The Role of Hypomethylating Agents

Novel Treatment Combinations in Development for AML: The Role of Hypomethylating Agents

CME, CPE
Ehab Atallah, MD
Release Date: October 30, 2017

Expiration Date: October 30, 2018

There is a significant unmet need in existing treatment paradigms for patients with acute myeloid leukemia (AML) due to poor survival and intolerability to cytotoxic chemotherapy, especially for a generally older patient population. Hypomethylating agents (HMAs) have demonstrated a benefit in patients with AML, especially those who require less aggressive therapy, but there is a need for improved efficacy and survival outcomes. In this activity, participants will learn about HMAs in existing treatment paradigms, as well as the investigational landscape of novel therapies in combination with HMAs, and their potential impact on treatment outcomes for patients with AML.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, Jazz Pharmaceuticals, Inc., and Novartis Pharmaceuticals.

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EHA 2017 Congress Highlights in Acute Myeloid Leukemia

EHA 2017 Congress Highlights in Acute Myeloid Leukemia

CME, CPE, CNE
Ehab Atallah, MD; Jorge E. Cortes, MD; Naval Daver, MD; Keith W. Pratz, MD; Eytan M. Stein, MD; Richard M. Stone, MD
Release Date: July 21, 2017

Expiration Date: July 21, 2018

In this activity, participants will learn about key highlights of the latest and most impactful data in acute myeloid leukemia (AML), presented at the 2017 European Hematology Association (EHA) 22nd Congress.

Chapter 1: Combination Therapy with Novel Agents and Chemotherapy Improves Survival in Diverse Subsets of AML Patients

Chapter 2: Safety and Efficacy of Enasidenib in Patients with Mutant-IDH2 Relapsed AML

Chapter 3: Improving Efficacy of Mutation-specific Therapeutic Options in AML: Emerging Data and Novel Agents

Chapter 4: Improved Efficacy, Safety with CPX-351 in Older Adults with Newly Diagnosed Therapy Related AML

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, Jazz Pharmaceuticals, Inc., and Novartis Pharmaceuticals.

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Tailoring Therapy to Older Patients with Acute Myeloid Leukemia

Tailoring Therapy to Older Patients with Acute Myeloid Leukemia

CME, CPE
Aziz Nazha, MD
Release Date: September 14, 2017

Expiration Date: September 14, 2018

Acute myeloid leukemia (AML) is generally a hematologic malignancy of older adults, with approximately 60% of newly diagnosed AML patients being 60 or older. Older patients pose unique therapeutic challenges that have been largely unmet to date. This activity will review and discuss decision-making strategies outlining when and how to treat this patient population in your practice. In addition, Dr. Nazha will provide an overview of the current treatment paradigms available, as well as agents currently approved or under investigation which may have a potential role in the outcome of the older patient with AML.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, Jazz Pharmaceuticals, Inc., and Novartis Pharmaceuticals.

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Breaking New Ground in AML: Practical Applications of Emerging Treatment Options

Breaking New Ground in AML: Practical Applications of Emerging Treatment Options

CME, CPE, CNE
Guillermo Garcia-Manero, MD; Jeffrey E. Lancet, MD; Elli Papaemmanuil, PhD; Richard Stone, MD
Release Date: July 21, 2017

Expiration Date: July 21, 2018

This activity has been developed from a live symposium held in conjunction with a clinical oncology meeting held in June 2017, focusing on the newest advancements in acute myeloid leukemia (AML). Drawing upon both clinical trial data and analysis of case vignettes, a distinguished faculty panel discusses not only new and emerging strategies in the diagnosis, prognosis, and treatment of AML, but also how these critical new advances will change practice in the near future.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Astellas, Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, and Jazz Pharmaceuticals.

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Exploring Epigenetics in AML Oncogenesis

Exploring Epigenetics in AML Oncogenesis

CME, CPE
Farhad Ravandi, MD
Release Date: June 23, 2017

Expiration Date: June 23, 2018

In acute myeloid leukemia (AML), several epigenetic pathways have been implicated in disease pathogenesis, including DNA methylation, histone acetylation, and histone methylation. Ongoing research is focusing on these epigenetic pathways for the development of novel agents and regimens across the disease lifecycle. Join Dr. Ravandi as he describes the molecular and cellular processes that are driving oncogenesis in AML, how the mechanisms of action of several new and emerging agents in AML target specific genetic mutations, and the critical implications for clinical practice.

Provided by MediCom Worldwide, Inc.
This activity is supported by educational grants from Agios Pharmaceuticals, Inc., Celgene Corporation, Helsinn Healthcare SA, Incyte Corporation, Jazz Pharmaceuticals, Inc., and Novartis Pharmaceuticals.

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